A neuroendocrine tumour is a rare tumour that can develop in many different organs of the body. It affects the cells that release hormones into the bloodstream (neuroendocrine cells).
Neuroendocrine tumours can be cancerous (malignant) or non-cancerous (benign). They often grow slowly, but not always.
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Symptoms of neuroendocrine tumours
The symptoms of a neuroendocrine tumour depend on where in the body it is and what hormones it produces.
A tumour in the lung (pulmonary neuroendocrine tumour) may cause wheezing or a persistent cough.
Some tumours may lead to abnormally large amounts of hormones being released into the bloodstream. These are known as "functioning tumours" and can cause symptoms such as diarrhoea, flushing, cramps, wheezing, low blood sugar (hypoglycaemia)彩之网首页, changes in blood pressure and heart problems.
Causes of neuroendocrine tumours
The cause of neuroendocrine tumours isn't fully understood. However, your chance of developing one is increased if you have one of the following inherited conditions:
- multiple endocrine neoplasia type 1 (MEN1)
- neurofibromatosis type 1
- Von Hippel-Lindau syndrome (VHL)
彩之网首页Research suggests your risk of developing a neuroendocrine tumour is slightly increased if your father, mother, brother or sister has had any type of cancer.
Diagnosing neuroendocrine tumours
Types of scans used include:
Treatment for neuroendocrine tumours
彩之网首页How a neuroendocrine tumour is treated will depend on your individual circumstances, such as:
- where the tumour is
- how advanced your condition is
- your overall health
Unfortunately, many people are only diagnosed after the tumour has spread to other parts of the body.
彩之网首页However, it may still be possible to use surgery to remove the tumour. If surgery can't completely cure your condition, it may be used to help reduce and manage any symptoms.
Medication called , such as octreotide or lanreotide, may be recommended. They stop your body producing too many hormones, and can reduce the severity of your symptoms and slow the condition's progression. You'll have an injection, usually once every 28 days.
It may also be possible to shrink the tumour or stop it growing using treatments that block its blood supply (embolisation), or using chemotherapy, radiotherapy or radiofrequency ablation (where heat is used to destroy the cells).
There are also two treatments – everolimus and sunitinib – that can be used to treat some neuroendocrine tumours in adults if:
- they can't be fully removed using surgery
- they've spread
- the symptoms are getting worse
彩之网首页Everolimus is taken as a tablet, and sunitinib is taken as a capsule.
The National Institute for Health and Care Excellence (NICE) has .
Cancer Research UK also has more information about .
Page last reviewed: 27 November 2017
彩之网首页 Next review due: 27 November 2020